The axio-somatic model and the evidence for the erythroblastic origin of adult stem cell in humans. 

 

                               

 

The origin of "adult" stem cell (near naked nuclei):  Non mitotic , by enucleation from the erythroblast.  On HE note the chromatin compaction and the degenerating erythroid plastid (acidophilic body)    

 

                                             

On Berg´s note  the red fuschinophilia (acid-fastness) 

 

 

           

Comparative study between male gametopoyesis  and hematopoyesis  with the Berg´s  method. Note in the testis the acid-fastness of gamete precursors and of spermatozoa. Segmentation of diploid nuclei. The germ line origin of acid-fast DNA-vectors . 

 

              

Hematopoyesis with  the Berg´s method. Note the red stained nuclei  in erythroid precursors and near naked nuclei (AF-NANU). The origin of acid-fast DNA vectors in axial hematopoyesis, from erythroblasts. 

 

 

              Note the nucleo-cytoplasmic uropod,in both the sperm and nanu.  

 

 

          

The erythroblastic origin of hematogones . Bone marrow hematopoyesis.: HE; nucleated erythroid precursors with compacted chromatin. Enucleating erythroblasts.Near naked nuclei (NANU) and variably hemoglobinized erythroid plastids (reticulocytes). 

         

Right side: Berg; red stained nuclei, acid- Fast- NANU. The erythroblastic origin of adult stem cell. 

 

            

Embryo 22 mms. 7 weeks. Neural blastema. Primary erythroblasts enucleating within the field. Note the nuclear compaction and acid-fastness of these nuclei. Variably hemoglobinized erythroid carcases, acidophilic bodies.  

            

 

AF.NANUS. The grafting of NANUS , virgin nuclei, probably contributes to the exponential  growth of embryo-fetal tissues by Karyoanabiosis. 

          

 

Foetus 22 weeks. Immature erythroblasts enucleating in peripheric somatic 

tissues. Note variably hemoglobinized reticulocytes, acidophilic bodies 

 

         

Acid-fast near naked nuclei contributing to the histogenesis of striated muscle. 

HE and Berg methods. 10 x 100. o.i. 

 

 

References: 

Palacios Llopis S :Thymic seminomas, acid fast thymocytes and Hassall´s bodies are all them expression of germ line differentiation. XVII World Congress of Anatomic and Clinical Pathology. Acapulco.Mexico. International Proceedings Division. Monduzzi Editore. 1994:355-359. 

 

 

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